Calcium-mediated one-pot preparation of isoxazoles with deuterium incorporation
نویسندگان
چکیده
منابع مشابه
One-pot synthesis of highly functionalized pyridines via a rhodium carbenoid induced ring expansion of isoxazoles.
A concise one-pot synthesis of highly functionalized pyridines has been developed. The first step in the reaction sequence is the formal insertion of rhodium vinylcarbenoids across the N-O bond of isoxazoles. Upon heating, the insertion products undergo a rearrangement to give 1,4-dihydropyridines. DDQ oxidation then affords the corresponding pyridines in 31-84% yield. The process has proven ge...
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Tetra-N-Butyl Ammonium Hydroxide was used as a catalyst for one-pot, three component condensation reactions consisting of aromatic aldehydes, malononitrile and barbituric acid in ethanol:water solvent system at 60oC. Current method has major advantages like mild reaction conditions with simple operation, high yields, by using a less toxic and lower costlier catalyst.In conclusion, we have explo...
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ژورنال
عنوان ژورنال: Organic Chemistry Frontiers
سال: 2018
ISSN: 2052-4129
DOI: 10.1039/c7qo00705a